The Mohlke Lab is located on the fifth floor of the Genetics Medicine Building at the University of North Carolina at Chapel Hill. We are identifying genetic variants and genes that influence common human traits with complex inheritance patterns, and we seek to understand the biological function of the identified variants and genes.
Currently, we are investigating susceptibility to type 2 diabetes and obesity, as well as variability in cholesterol levels, blood pressure, body size, weight gain and early growth. In addition to examining the primary effects of genes, the lab is exploring the interaction of genes with environmental risk factors in disease pathogenesis. Approaches include genome-wide association studies, cellular and molecular biology, genetic epidemiology, bioinformatic analysis of genome-wide epigenomic datasets and resequencing.
We are involved in many international consortia and collaborations including FUSION, CLHNS, METSIM, CHNS, GIANT, DIAGRAM, GLGC, AGEN, MAGIC, ICBP, EGG and ADIPOGEN. For more information about our ongoing research projects please visit our research page.